THE MOLE CRICKET—GRYLLOTALPA BOREALIS

The Aurora and Borealis Stream Processing Engines

Over the last several years, a great deal of progress has been made in the area of stream-processing engines (SPEs) [9, 11, 17]. Three basic tenets distinguish SPEs from current data processing engines. First, they must support primitives for streaming applications. Unlike Online Transaction Processing (OLTP), which processes messages in isolation, streaming applications entail time series oper...

The eye of the mole.

Mole Tar

Downloa ent advances in understanding the role of eukaryotic translation initiator factor 4E (eIF4E) in igenesis and cancer progression have generated significant interest in therapeutic agents that ctly or directly target aberrant activation of eIF4E in cancer. Here, we address the general function 4E in translation initiation and cancer, present evidence supporting its role in cancer initiati...

Mole Evid

Downlo ptive response (AR) is a term describing resistance to ionizing radiation–induced killing or formation of nt chromosomes that is mediated by pre-exposure to low ionizing radiation doses. The mechanism of ains elusive. Because cell killing and chromosome aberration formation derive from erroneous procesf DNA double-strand breaks (DSB), AR may reflect a modulation of DSB processing by nonh...

Mole Tar

Download wth factors and many oncogenes activate the lipid kinase phosphoinositide 3-kinase (PI3K), ing a signaling cascade that includes the protein kinases AKT and target of rapamycin (TOR). The AKT/TOR signaling pathway is a significant contributor to disease in various human cancers, includmatologic malignancies. Here we discuss different strategies to inhibit TOR for the treatment of ia, l...